The actinin family proteins: biological function and clinical implications

Cerato-platanin family proteins: one function for multiple biological roles?

INTRODUCTION Despite the increasing number of sequenced genomes, cerato-platanin family proteins (CPPs) seem to exist only in fungi. Bacteria, oomycota, plants, and animals do not in fact possess CP homologs, whereas genes codifying for CPPs have been found, so far, in more than 50 fungal genomes (Chen et al., 2013). Among these fungi there are plant pathogens, such as Botrytis cinerea and Magn...

Insights into biological functions across species: examining the role of Rab proteins in YIP1 family function.

The YIP1 family comprises an evolutionarily conserved group of membrane proteins, which share the ability to bind di-prenylated Rab proteins. The biochemical capability of YIP1 family proteins suggests a possible role in the cycle of physical localization of Rab proteins between their cognate membranes and the cytosol. YIP1 is essential for viability in yeast and a deletion of YIP1 can be rescu...

The Promyelocytic Leukemia Protein, PML, and Its Biological Function

Fibrogenesis: Mechanisms, Dynamics and Clinical Implications

Fibrosis is the pathological condition resulting in the growth of excess fibrous connective tissue in an organ or body system as a reparative or reactive process. In the field of clinical pathology, clinicians and medical scientists are endeavoring to translate experimental knowledge into effective, innovative treatments for a range of fibrotic conditions. The amelioration of whole organ functi...

Heat Shock Proteins and their clinical Implications

Knowledge of the physiological role of heat shock proteins is currently limited; however better understanding of their function and thereby the acquisition of the capacity to harness their power might lead to their use as therapeutic agents and revolutionize clinical practice in a number of areas. Future work is needed to translate the experimental data on the capacity of heat shock proteins to...